Homepage of Matthias Pursch

Research Projects

• Synthesis of stationary interphases with extended alkyl chains (C-18, C-22, C-30) for liquid chromatography.

• Investigations on structure, order and dynamic behavior of bonded phases by multinuclear and multidimensional solid-state NMR spectroscopy ( ¹ H, ¹³ C, ²⁹ Si; 2D WISE).

• High-resolution MAS NMR investigations of polymer resins for combinatorial chemistry.

• HPLC evaluation of reversed-phase columns by separations of shape-selectivity PAH's mixtures.

• Investigations of organic interphases and polymers by dipolar filter and 2D WISE NMR techniques.

• Member of the interdisciplinary research group "Chemistry in Interphases" (DFG).

• Collaboration with the Analytical Chemistry Division at the NationalInstitute of Standards and Technology (NIST)(internet-link: "http://www.nist.gov") , Gaithersburg, MD, USA.

Publications

• Pursch, M.; Strohschein, S.; Händel, H.; Albert, K. Anal. Chem. 1996 , 68 , 386-393. "Temperature-dependent behavior of C ₃₀ Interphases. A solid-state NMR and LC-NMR study."
  
• Albert, K.; Händel, H.; Pursch, M.; Strohschein, S. in Chemically Modified Surfaces , The Royal Chemical Society: Cambridge, 1996 p.30-45. "Solid-state NMR characterization of C ₃₀ bonded interphases and their application in on-line HPLC-NMR spearation chemistry of Vitamin A-Acetate isomers."

• Pursch, M.; Jäger, A.; Schneller, T.; Brindle, R.; Albert, K.; Lindner, E. Chem. Mater. 1996 , 8 , 1245-1249. "The sol-gel method: A new way to reversed phase materials. Synthesis and characterization by solid-state NMR spectroscopy."

• Brindle, R.; Pursch, M.; Albert, K. Solid-State NMR 1996 6 , 251-266. " ¹ H MAS NMR spectroscopy of chemically modified silica gels: a fast method to characterize stationary interphases for chromatography."

• Pursch, M.; Sander, L.C.; Albert, K. Anal. Chem. 1996 68 , 4107-4113. "Investigations on chain order and mobility of high-density C ₁₈ phases by solid-state NMR spectroscopy and liquid chromatography".

• Pursch, M.; Schlotterbeck, G.; Tseng, L.H.; Albert, K.; Rapp, W. Angew. Chem. Int. Ed. Engl. 1996 , 35, 2867-2869. "Monitoring of the reaction progress in combinatorial chemistry: ¹ H MAS NMR investigations on single macro beads in the suspended state."

• Strohschein, S.; Pursch, M.; Händel, H.; Albert, K. Fresen. J. Anal. Chem. 1997 , 357. "Structure elucidation of b-carotene isomers by HPLC-NMR coupling using a C ₃₀ bonded phase."

• Strohschein, S.; Schlotterbeck, G.; Richter, J.; Pursch, M.; Tseng, L.-H.; Händel, H.; Albert, K. J. Chromatogr. 1997 , in press: "Comparison of the separation of cis/trans isomers of tretionin isomers with different stationary phases by LC-NMR coupling."

• Lynch, B.; Glennon, J.; Menyes, U.; Tröltzsch, C.; Pursch, M.; Albert, K. Anal. Chem. 1997 in press: "A new (-)-menthyl bonded silica phase for chiral separations: synthesis and solid-state NMR characterization."

• Albert, K.; Häfelinger, G.; Milart. P.; Krygowski, T.M.; Kühn, T.; Pursch, M.; Strohschein, S. Z. Naturforsch . 1997 , in press. äConformational Aspects of the p-Nitrosophenolate Anion and Related Compounds: NMR Study and ab initio 6-31G Optimizations of Molecular Structures.ô

• Pursch, M.; Brindle, R.; Ellwanger, A.; Sander, L.C.; Bell, C.B.; Händel, H.; Albert, K. Solid State Nucl. Magn. Reson. 1997 , in press: äStationary Interphases with extended alkyl chains. A comparative study on chain order by solid-state NMR spectroscopyô.

• Pursch, M.; Albert, K. in Analytical Tool and Quality Control for Libraries, Combinatorial Techniques in Drug Discovery , Marcel Dekker, New York, manuscript prepared. äThe Potential of High-Resolution MAS NMR Spectroscopy as Analytical Tool for Libraries.ô

• Strohschein, S.; Pursch, M.; Lubda, D.; Albert, K. Anal. Chem submitted for publication äShape Selectivity of C ₃₀ phases for RP-HPLC Separation of Tocopherol Isomers and Correlation with ¹³ C MAS NMR Data of Bonded Phases in the Susepended-State.ô

Any questions or personal information wanted? Please email to: matthias.pursch@uni-tuebingen.de

Last update 4. April 1997

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(coisg01@uni-tuebingen.de) Last change: April 1997

Internet-Links

NationalInstitute of Standards and Technology (NIST)(http://www.nist.gov)